![]() ![]() ![]() Protein binding is low, about 36%, and muscle tissue binding is reported as 54%. Morphine has an apparent volume of distribution ranging from 1.0 to 4.7 L/kg after intravenous dosage. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. The μ-binding sites of opioids are very discretely distributed in the human brain, with high densities of sites found in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen and certain cortical areas. Morphine interacts predominantly with the μ-receptor. A systemically administered opiate may produce analgesia by acting at any, all or some combination of these distinct regions. Opiate analgesia involves at least three anatomical areas of the central nervous system: the periaqueductal-periventricular gray matter, the ventromedial medulla and the spinal cord. Morphine produces a wide spectrum of pharmacologic effects including analgesia, dysphoria, euphoria, somnolence, respiratory depression, diminished gastrointestinal motility and physical dependence. Each ampule and vial is intended for SINGLE USE ONLY. Ampules and vials are sealed under nitrogen. Each milliliter contains morphine sulfate 0.5 mg or 1 mg and sodium chloride 9 mg in Water for Injection. Preservative-free ASTRAMORPH/PF (Morphine Sulfate Injection, USP) is a sterile, nonpyrogenic, isobaric solution of morphine sulfate, free of antioxidants, preservatives or other potentially neurotoxic additives and is intended for intravenous, epidural or intrathecal administration as a narcotic analgesic. It is available as the sulfate salt, having the following structural formula:ħ,8-Didehydro-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3,6-diol sulfate (2:1) (salt), pentahydrate Morphine is the most important alkaloid of opium and is a phenanthrene derivative. Astramorph/PF ™ ( Morphine Sulfate Injection, USP) Preservative-Free ![]()
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